Tat is required for efficient HIV-1 reverse transcription

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Tat is required for efficient HIV-1 reverse transcription.

The ability of human immunodeficiency virus-1 (HIV-1) to undergo efficient reverse transcription is dependent on a number of parameters. These include the binding of the tRNA(3)(Lys) to the HIV-1 primer binding site and the subsequent interaction with the heterodimeric reverse transcriptase. Recently, we demonstrated that TAR RNA was also necessary for efficient HIV-1 reverse transcription. Giv...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 1997

ISSN: 1460-2075

DOI: 10.1093/emboj/16.6.1224